Ezio BONVINI;Paul A. MOORE;Kalpana SHAH;MACROGENICS INC.;Douglas H. SMITH;ROSS LA MOTTE-MOHS;SCOTT KOENIG;Lesile S. JOHNSON
发明人:
ROSS LA MOTTE-MOHS,SCOTT KOENIG,Kalpana SHAH,Ezio BONVINI,Paul A. MOORE,Douglas H. SMITH,Lesile S. JOHNSON
申请号：
IL25617917
公开号：
IL256179D0
申请日:
2017.12.07
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
The present invention is directed to the anti-LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3-binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.
