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oligosaccharide chain added glp-1 peptide
专利权人:
OTSUKA CHEMICAL CO.; LTD.
发明人:
HIROAKI ASAI,IZUMI SAKAMOTO,KATSUNARI TEZUKA,KAZUHIRO FUKAE,KAZUYUKI ISHII,NAOHIRO HAYASHI,TAKASHI TSUJI,YASUHIRO KAJIHARA,YURI NAMBU
申请号:
BRPI0914889
公开号:
BRPI0914889A2
申请日:
2009.06.15
申请国别(地区):
BR
年份:
2015
代理人:
摘要:
An object of the present invention is to provide an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention provides an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least two amino acids are each substituted with an oligosaccharide chain added amino acid, in (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog. The present invention also provides an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in the (a), (b) or (c) and the oligosaccharide chain is an oligosaccharide chain comprising oligo hyaluronic acid. In the oligosaccharide chain added amino acid, the oligosaccharide chain may be linked to the amino acid via a linker.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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