DR. COLLIN-KRPELIN, MARIE,PIERRE - DR. KOLKHOF, PETER,DR. NEUBAUER, THOMAS,DR. FRSTNER, CHANTAL,DR. POOK, ELISABETH,DR. WITTWER, MATTHIAS BEAT,DR. SCHMECK, CARSTEN,DR. WASNAIRE, PIERRE,DR. SCHIRMER, H
申请号：
ARP180103099
公开号：
AR113791A1
申请日:
2018.10.24
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
The report refers to 3 - (3 - (3 - (4-chlorophenyl) 3 - (3 - (4-chlorophenyl) 3 - (3 - (4-chloropphenyl) - 5-oxo-4 - [(2S) - 3, 3, 3-three-three-three - [three - [three - (trifluoromethane) - 1-1-1-1-1-1-1-1-1-1-1-1,2, 4-3-3 [trifluoro [trifluodifluorbis] 3-3 - [trifluofluoride [trifluofluoride] 3 - [triflfluorine (TRI) - 3 - [trifluoride] 3 - [trifluo [trifluo [trifluo [trifluo [trifluo [trifluo [trifluo [trifluo [trifluo [trifluo [trifluo [trifluo [trifluo [three [three [three [three [three [three [three [three [three [three(tri - [tri - [tri - [tri]]]]] - 3 - [trifluoro-4,5-dihydro-1h-1,2, (1-1-1-1-1-bis (1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-bis (1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-this compound contains the preparation process of this compound and the preparation process of this compound chemical compound,And use such compounds or ingredients to treat and / or prevent diseases, especially kidney and cardiovascular diseases. 1. Claim 1: compound (1) of the general formula,R1 represents a formula group (2) or (3) or (4),Here, it represents the binding point with the 1,2,4-triadiene ring or one of the drugs acceptable salts, solutions or solutions of these salts.La presente se refiere a profármacos 3-(3-(4-clorofenil)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hidroxipropil]-4,5-dihidro-1H-1,2,4-triazol-1-ilmetil)-1-[3-(trifluorometil)-piridin-2-il]-1H-1,2,4-triazol-5-carboxamida, 3-(3-(4-clorofenil)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hidroxipropil]-4,5-dihidro-1H-1,2,4-triazol-1-ilmetil)-1-[2-(trifluorometil)-fenil]-1H-1,2,4-triazol-5-carboxamida y 3-(3-(4-clorofenil)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hidroxipropil]-4,5-dihidro-1H-1,2,4-triazol-1-ilmetil)-1-(3-cloropiridin-2-il)-1H-1,2,4-triazol-5-carboxamida, a procesos para la preparación de tales compuestos, a composiciones farmacéuticas que contienen tales compuestos, y al uso de tales compuestos o composiciones pa
