ANTICORPS D'ISOTYPE IgG1 MUTÉS DANS LEUR PARTIE Fc AFIN D'AUGMENTER LEUR LIAISON AVEC LE FcRn ET LEUR UTILISATION

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专利权人:

BOARD OF REGENTS; THE UNIVERSITY OF TEXAS SYSTEM

发明人:

申请号：

EP06784551.1

公开号：

EP1896503B1

申请日:

2006.05.31

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The present invention provides for IgG1 molecules with improved characteristics. In particular, substitution mutations are provided that, in combination, facilitate improved placental transfer, improved serum half-life and improved FcRn binding. Substitution mutations are also provided, that in combination, can be used to block FcRn function and thereby increase the clearance rates of other (endogenous or exogenous) IgGs, block placental transport of IgGs and have increased affinity/reduced pH dependence for FcRn binding.

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