Compositions comprising a protein or isolated peptide, and methods using the same for preventing, dispersing or detaching a biofilm, are disclosed. 120% 110% 100% -90% -80% * Eqt2Z-cyclong/m7 * Eqt2Z-cyclOOng/mi 60% " Eqt2Z-cyc1pg/ml 50% * P.a control - 40% - 30% 20% - 10% 0%