FIELD: chemistry.SUBSTANCE: invention relates to field of organic chemistry, namely to heterocyclic compounds of general formula(I) and to their pharmaceutically acceptable salts, where each W, X, Y and Z represents CH； each W, X and Y represents CH and Z represents N or each W, X and Z represents CH and Y represents N； D and Dare independently selected from bond or NR； A represents chinolinyl； L is bond, -C(O)-, -(CRR)-, -OC(O)-, -(CRR)-OC(O)-, -(CRR)-C(O)-, -NRC(S)- or -NRC(O)- (where point of binding to Ris on the left side)； Ris selected from C-Calkyl, C-Ccycloalkyl, aryl (where aryl represents phenyl or naphthyl), heteroaryl (where heteroaryl represents 5-10-membered mono- or bicyclic aromatic ring with 1-3 heteroatoms, selected from nitrogen and sulphur) and heterocyclyl (where heterocyclyl represents tetrahydrofuranyl or azetidinyl) each of which is substituted with 0-5 substituents R； each Ris independently selected from halo-C-alkyl, C-Calkyl, hydroxyl and -OR； each Ris independently selected from C-Calkyl and acyl (where acyl represents -C(O)CH), hydroxy-C-Calkyl； each Ris independently selected from hydrogen and C-Calkyl； each Ris independently selected from hydrogen, C-Calkyl or two R, taken together with atoms of carbon, which they are bound to, form C-cycloalkyl； each Ris independently selected from halo-C-alkyl, halo-C-alkoxy, C-Calkyl, C-Calkinyl, cyano, hydroxyl, -C(O)R, -OC(O)R, -C(O)OR, -SR, -NRRand -OR； n equals 0 or 1； m equals 1, 2 or 3； h equals 1 or 2 and g equals 1. Invention also relates to particular compounds, pharmaceutical composition, based on formula (I) compound and method of modulating PKM2 activity.EFFECT: novel heterocyclic compounds, useful for modulating PKM2 activity, have been obtained.46 cl, 1 dwg, 2 tbl, 2 exИзобретение относится к области органической химии, а именно к гетероциклическим соединениям общей формулы (I) и к его фармацевтически приемлемым солям, где каждый W, X, Y и Z представляет CH； каждый W, X и Y представляе
