Systems, devices and methods for electric stimulation are provided. The system comprises an electrodes arrangement configured to be placed in the vicinity of a body region to be stimulated a signal generator configured to supply electric stimulation signals to the electrodes arrangement and a control circuitry connected to the signal generator and to the electrodes arrangement the electrodes arrangement comprises a plurality of electrode elements arranged in a spaced-apart relationship and being connected to the signal generator, so as to define spatial resolution of stimulation the control circuitry determines data indicative of a profile of a stimulating electric field to be produced by the electrodes arrangement to stimulate at least one desired target in said body region, and selectively assign, for stimulating each target, at least one pair of first and second effective electrodes, each being formed by one or more of said electrode elements, and enable operation of each of said assigned effective electrodes by the signal generator to produce the stimulating electric field.
