toripepuchido and tetra- peptide thioether, the medicine composition which includes that, the medicine use and the production. As for the said chemical compound, Shank of the GM precusor production in selective poisonous grant and the marrow cell in the reinforcement and the tumor cell of the cell poisonous effect of the chemotherapeutic agent in the tumor cell, it is useful in stimulus of marrow differentiation, relief of marrow control action of the chemotherapeutic agent and the adjustment of the hemotopoiesis in the marrow.トリペプチドおよびテトラペプチドチオエーテル、それを含む医薬組成物、その医薬的使用ならびにその製造。該化合物は、腫瘍細胞における化学療法剤の細胞毒性効果の増強、腫瘍細胞における選択的毒性付与、骨髄細胞におけるGM前駆体産生の亢進、骨髄分化の刺激、化学療法剤の骨髄抑制作用の緩和および骨髄における造血の調節に有用である。