凝血酶受體拮抗劑之立即釋放錠劑調配物农业专利-农业学术服务平台

发明人:: GUPTA, RAJAN,雷杰　古塔,雷傑　古塔,CHAWDRY, SULIMAN,苏利曼　查德瑞,蘇利曼　查德瑞,DUGGIRALA, SRINIVAS S.,史维尼瓦斯Ｓ　道吉雷拉,史維尼瓦斯Ｓ　道吉雷拉,雷杰古塔,雷傑古塔,苏利曼查德瑞,蘇利曼查德瑞,史维尼瓦斯S 道吉雷拉,史維尼瓦斯S 道吉雷拉

摘要：: Immediate-release formulations for oral administration of a thrombin receptor antagonist are provided. Certain formulations of higher API loading demonstrate sufficient moisture uptake after storage at stressed conditions to retard dissolution. The formulations of the present invention incorporate either lower API loading or elevated disintegrant-to-API ratios, found necessary to achieve disintegration rates required for immediate-release performance.本發明提供用於口服凝血酶受體拮抗劑之立即釋放調配物。API負荷較高之特定調配物在加壓條件下儲存後顯示會吸取充足之水分從而延遲溶解。本發明之調配物併入發現為達到立即釋放效能所需之崩解速率所需之較低API負荷或升高之崩解劑/API比率。