HIGH DENSITY EPIDURAL STIMULATION FOR FACILITATION OF LOCOMOTION, POSTURE, VOLUNTARY MOVEMENT, AND RECOVERY OF AUTONOMIC, SEXUAL, VASOMOTOR, AND COGNITIVE FUNCTION AFTER NEUROLOGICAL INJURY
Victor Reggie Edgerton;Mandheerej S. Nandra;Joel W. Burdick;Yury Gerasimenko;Thomas Anthony Desautels;Yu-Chong Tai;Susan J. Harkema;Jonathan Hodes;Roland R. Roy;Claudia A. Angeli
发明人:
Victor Reggie Edgerton,Roland R. Roy,Yury Gerasimenko,Joel W. Burdick,Susan J. Harkema,Jonathan Hodes,Yu-Chong Tai,Mandheerej S. Nandra,Claudia A. Angeli,Thomas Anthony Desautels
申请号：
US13978035
公开号：
US20140163640A1
申请日:
2012.01.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and/or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and/or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.
