Ying Zhou,Theodore H. Gasteyer, III,Nigel J. Grinter,Alan T. Cheng,Yeu-Chuan Simon Ho,Robert R. Sever
申请号：
US13097724
公开号：
US08794013B2
申请日:
2011.04.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.
