Antibodies and their use

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专利权人:

ＴＡＯヘルスライフファーマ株式会社;TAOヘルスライフファーマ株式会社

发明人:

星 美奈子,佐藤 道夫,井手野 祥次,内藤 幸嗣,保理江 智,野田 宗宏,堀井 肇

申请号：

JP2015106830

公开号：

JP6128535B2

申请日:

2015.05.26

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid ² fibrils or monomeric amyloid ²-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid ² fibrils； (ii) a higher reactivity with amylospheroids than with monomeric amyloid ²-proteins； and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/