PROBLEM TO BE SOLVED: To provide a search for an intraocular pressure-lowering agent having a new action mechanism.SOLUTION: A peptide derivative of the general formula (1) strongly and continuously lowers rabbit intraocular pressure by anterior chamber administration or eye drop, so is expected to be a new glaucoma therapeutic agent. (In the formula, R1 represents a 2-naphthoylamino group or the like X represents a carbon atom or the like the dash line represents a double bond or the like Y represents -CH2CO- or the like and Z represents a covalent bond or the like R2 represents a 2-methylbutyl group or the like.)COPYRIGHT: (C)2014,JPO&INPIT【課題】新たな作用機序を有する眼圧下降剤を探索すること。【解決手段】下記一般式(1)ペプチド誘導体は前房内投与または点眼により、ウサギの眼圧を強力且つ持続的に下降させることから、新たな緑内障の治療剤となることが期待される。[式中、R1は2-ナフトイルアミノ基などを示し;Xは炭素原子などを示し;破線は二重結合などを示し;Yは-CH2CO-などを示し;Zは共有結合などを示し;R2は2-メチルブチル基などを示す。]【選択図】図1
