COMPUESTOS DERIVADOS DE 8-[6-[3-(AMINO)PROPOXI]-3-PIRIDIL]1-ISOPROPILIMIDAZO[4,5-C]QUINOLIN-2-ONA, MODULADORES SELECTIVOS DE LA CINASA DE LA ATAXIA TELANGIECTASIA MUTADA (ATM)； COMPOSICION FARMACEUTICA； USO EN EL TRATAMIENTO DEL CANCER.
BARLAAM, Bernard Christophe,PIKE, Kurt Gordon,HUNT, Thomas Anthony,EATHERTON, Andrew John
申请号：
CL2018000677
公开号：
CL2018000677A1
申请日:
2018.03.14
申请国别(地区):
CL
年份:
2018
代理人:
摘要：
and pharmaceutically acceptable salts thereof, where R1, R2, R3, R4 and R5 have any of the meanings defined herein. The specification also relates to the use of compounds of Formula (I) and salts thereof to treat or prevent ATM mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising substituted imidazo[4,5-c]quinolin-2-one compounds and pharmaceutically acceptable salts thereof； kits comprising such compounds and salts； methods of manufacture of such compounds and salts； and intermediates useful in such manufacture.DERIVADOS DE 8-[6-[3-(AMINO)PROPOXI]-3-PIRIDIL]1-ISOPROPILIMIDAZO[4,5-C]QUINOLIN-2-ONA COMO MODULADORES SELECTIVOS DE LA CINASA DE LA ATAXIA TELANGIECTASIA MUTADA (ATM) PARA EL TRATAMIENTO DEL CÁNCER
