ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人:
PORCELLI, STEVEN A.
申请号：
CA2577009
公开号：
CA2577009C
申请日:
2005.08.26
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
.alpha.-Galactosylceramides and glycosylceramides ("ceramide-likeglycolipids") that modulate NK T cells. The ceramide-like glycolipids vary inthe cytokines induced in NK T cells and vary in the antigen-presenting cellsthat are capable of efficiently presenting the compounds to NK T cells.Pharmaceutical compositions of the ceramide-like glycolipids are provided, asare pharmaceutical compositions of the ceramide-like glycolipids combined withdendritic cells. Methods utilizing the ceramide-like glycolipids in vaccines,to activate NK T cells, to stimulate the immune system, and to treat mammalsare also provided. The invention also provides methods of evaluating acompound for its ability to activate an NK T cell in the presence of a cellexpressing a CD 1 d protein.
