SE CHANG KWON,SUNG YOUB JUNG,SUNG MIN BAE,SANG YUN KIM,JONG MIN LEE,JUNG KUK KIM
申请号：
ARP150104340
公开号：
AR103322A1
申请日:
2015.12.30
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Claim 1: A glucagon derivative, which comprises the amino acid sequence of the following general formula (1) and has a different isoelectric point (pl) from that of the native glucagon: X¹-X²-QGTF-X⁷-SDYS-X¹²-X¹³ -X¹⁴-X¹⁵-X¹⁶-X¹⁷-X¹⁸-X¹⁹-X²⁰-X²¹-F-X²³-X²⁴-WL-X²⁷-X²⁸-T (general formula (1)) where, in the general formula (1),X¹ is histidine, deamino-histidine, N-dimethyl-histidine, b-hydroxyimidazopropionic acid, 4-imidazoacetic acid, b-carboxyimidazopropionic acid, tryptophan, tyrosine, or is eliminated； X² is a-methyl-glutamic acid, aminoisobutyric acid (Aib),D-alanina glicina Sar (N-metilglicina)serina o D-serina X es treonina o valina X es lisina o ciste na X es tirosina o ciste na X es leucina o ciste na X es cido asp rtico cido glut mico o ciste na X es cido glut mico cido asp rtico serina cido a X es valina leucina glutamina o arginina X es isoleucina o metionina y X es arginina o asparagina (con la condici n de que cuando la secuencia de amino cidos de f rmula general (1) es id ntica a SEC ID N 1 la misma es excluida In this case, the drug ingredients are administered separately or jointly with a pharmacist who has the effect of preventing or treating obesity. Claim 15: the use of a glucose derivative, or a drug containing the derivative, in accordance with any claims 1 to 4 for the preparation of a drug to prevent or treat obesity.Reivindicación 1: Un derivado de glucagón, que comprende la secuencia de aminoácidos de la siguiente fórmula general (1) y tiene un diferente punto isoeléctrico (pl) de aquel del glucagón nativo: X¹-X²-QGTF-X⁷-SDYS-X¹²-X¹³-X¹⁴-X¹⁵-X¹⁶-X¹⁷-X¹⁸-X¹⁹-X²⁰-X²¹-F-X²³-X²⁴-W-L-X²⁷-X²⁸-T (fórmula general (1)) en donde, en la fórmula general (1), X¹ es histidina, desamino-histidina, N-dimetil-histidina, ácido b-hidroxiimidazopropiónico, ácido 4-imidazoacético, ácido b-carboxiimidazopropionico, triptófano, tirosina, o está eliminado； X² es ácido a-metil-glutámico, ácido aminoisobutírico (Aib), D-alanina, glicina, Sar(N-metilglicina), serina, o
