A three-dimensional nonwoven fabric with a pore structure includes raised regions, recessed regions, and the pore structure. Fiber densities from the raised regions to the recessed regions are gradient. That is, the fiber density of the edges transiting from the raised regions to the recessed regions is higher than that of the tops of the raised regions. Pressure resistance performance of the high-density fiber regions keeps the three-dimensional nonwoven fabric significantly uneven, and quickens liquid permeation and reduces residues, and the three-dimensional nonwoven fabric has a high permeating speed and is dry and comfortable.