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DRUGS AND METHODS FOR OBTAINING DRUGS FOR USE IN EMPTY DRAGES
专利权人:
РЕДХИЛЛ БАЙОФАРМА ЛТД. (IL)
发明人:
ФАТХИ Реза (US),МАКЛИН Патрик Лафлин (CA)
申请号:
RU2015106688
公开号:
RU2015106688A
申请日:
2013.07.26
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method for producing a solid drug preparation comprising: (i) wet granulating at least one osmotic laxative, at least one antacid and a first pharmaceutically acceptable excipient component to form an intragranular fraction; (ii) mixing the intragranular fraction obtained in step (i) with components of an extragranular fraction containing one or more organic acids, a non-metallic lubricant and a second pharmaceutically acceptable excipient component t; and (iii) compressing the mixture of step (ii) into tablets. 2. The method of claim 1, further comprising (iv) coating the tablets with a coating. A method according to claim 1, wherein the content of the intragranular fraction is approximately 50% of the total weight of the preparation and in which the content of the extragranular fraction is approximately 50% of the total weight of the preparation. The method of claim 1, wherein the first pharmaceutically acceptable excipient component comprises at least one binder, diluent, stabilizing agent, disintegrant, anti-foaming agent, anti-adhesive or anti-foaming agent. The method of claim 1, wherein the second pharmaceutically acceptable excipient component includes at least one binder, diluent, stabilizing agent, disintegrant, anti-foaming agent, anti-adhesive or anti-foaming agent. The method of claim 1, wherein the first pharmaceutically acceptable excipient component comprises a first amount of a diluent and the second pharmaceutically acceptable excipient component comprises1. Способ получения твердого лекарственного препарата, содержащий:(i) влажное гранулирование по меньшей мере одного осмотического слабительного средства, по меньшей мере одного антацида и первого фармацевтически приемлемого компонента-эксципиента с образованием интрагранулярной фракции;(ii) смешивание интрагранулярной фракции, полученной на стадии (i), с компонентами экстрагранулярной фракции, содержащей одну или несколько органических кислот, неметаллическое смазующее вещество и второй фарма
来源网站:
中国工程科技知识中心
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