A manifold for loading plural cannulae with a substance The manifold includes a housing with a plurality of channels that route the flow of the mixed substance from a single central channel to multiple sub-channels for the simultaneous filling of attached cannulae. Each sub-channel extends to a fitting to which a cannula may be attached. The fittings are rotatably mounted to the housing. A lock assembly holds the cannulae to the individual fittings are so that when a cannula is removed from a fitting, the fitting rotates so as to close the fluid path from the sub-channel. In order to attach a second cannula to the same fitting the lock system requires the fitting to be rotates into a position in which the fluid communications path from the associated sub-channel is reopened.
