A system comprises: an isolation tube (42, 82) extending into a clean area (14), the isolation tube having a closed end (44) and an opposite open end (46) that is open to a contamination area (12) adjacent the clean area in order to receive an imaging subject from the contamination area and an imaging apparatus (40, 80) disposed in the clean area and movable along the isolation tube in order to image a subject in the isolation tube at a plurality of different positions along the isolation tube. In some more specific embodiments, the system further includes a vehicle (10) having an interior including the contamination area (12) and the adjacent clean area (14) wherein the system is a mobile imaging unit.