The present disclosure relates to systems, methods, and uses of systems treating a skin condition with phototherapy. A system comprises (a) a phototherapy device comprising a phototherapy light source； (b) a patient computing device comprising a processor and a memory, the patient computing device configured to: transmit a first signal to the phototherapy device enabling operation of the phototherapy device according to one or more conditional prescription parameters, activate the phototherapy light source, and transmit a second signal reporting operation of the phototherapy device； and (c) a server configured to communicate with the patient computing device and receive the second signal. Also disclosed are systems, methods and compositions for controlling phototherapy treatments of the skin.
