Describes a fusion protein containing a protein half-life extension, a Linker, and a gdf15 Protein.Are described, in addition, Nucleic Acids encoding the fusion protein of the recombinant cells.Compositions comprising fusion proteins and Methods of using fusion proteins for the Treatment or prevention of Metabolic Diseases, Disorders or conditions.Claim 13: a fusion protein comprising an Amino Acid Sequence that is at least 90% Sequence identity with the sec. With no ident.5: 25 - 30, 36, 37, 40, 48, 55, 56, 59, 60, 64, 75, 92, 113, 115, 117, 119, 121, 123, 125 or 127.Claim 15: an isolated Nucleic Acid Molecule comprising a Nucleotide sequence encoding the fusion protein according to any of claims 1 to 14.Claim 37: a dimer comprising (i) a First polypeptide Chain comprising a First region of HSA in the n-terminus,A Linker, and a First gdf15 region at the c-terminus and (ii) a Second polypeptide Chain comprising a Second gdf15 region, where the region of HSA comprises a secuenciTo have at least 90% amino acid identity with the sec. With no ident.1, 2, or 3 and where the first gdf15 region comprises an Amino Acid Sequence that is at least 90% identity with the sec. With no ident.: 6, 7, 8, 9, 10, or 11 and the Second Region gdf15 comprises an Amino Acid Sequence that is at least 90% identity with the sec. With no. of ident: 6, 7, 8, 9, 10 or 11.Se describen proteínas de fusión que contienen una proteína de extensión de la semivida, un enlazador y una proteína GDF15. Se describen, además, ácidos nucleicos que codifican las proteínas de fusión, células recombinantes de estos, composiciones que comprenden las proteínas de fusión y métodos de usar las proteínas de fusión para el tratamiento o prevención de enfermedades metabólicas, trastornos o afecciones. Reivindicación 13: Una proteína de fusión que comprende una secuencia de aminoácidos que tiene al menos 90% de identidad de secuencia con las sec. con núm. de ident.: 5, 25 - 30, 36 - 37, 40, 48, 55 - 56, 59 - 60, 64 -
