Methods and compositions for combinatorial-based production of multivalent recombinant antigens

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专利权人:

W. Dorsey Stuart

发明人:

W. Dorsey Stuart,Edward B. Cambareri

申请号：

US11577303

公开号：

US08163533B2

申请日:

2005.10.17

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent.

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