1. A method of treating Alzheimers disease in a mammal comprising administering to the cerebrospinal fluid (cerebrospinal fluid, CSF) rAAV particles mammal, comprising a capsid protein and rAAV vector comprising a nucleic acid encoding a protective protein ApoE isoform inserted between a pair of AAV inverted terminal repeats thus which is effective for infection of ependymal cells in a mammal, wherein ependymal cell secretes ApoE to treat disease.2. Delivery Method protective isoforms of ApoE in the central nervous system of the mammal, comprising administering into the cerebrospinal fluid (CSF) mammalian particles rAAV, containing the capsid protein of AAV and a vector comprising a nucleic acid encoding protective isoform ApoE inserted between a pair of inverted terminal repeats AAV manner that It is effective for infection of ependymal cells in a mammal, e.g. ependymal cells secreting ApoE mlekopitayuschego.3 in CSF. A method of treating a disease in a mammal comprising administering to ependymal cells of a mammal the particles rAAV, containing the capsid protein of AAV and a vector comprising a nucleic acid encoding protective isoform protein ApoE inserted between a pair of inverted terminal repeats AAV thus, by which the nucleic acid delivery ependymal cell where ependymal cell secretes the protein ApoE to treat zabolevaniya.4. Delivery Method nucleic acid encoding ApoE isoform protective ependymal cell in a mammal comprising administering to ependymal cell particles rAAV, comprising AAV capsid protein and a vector comprising a nucleic acid Sun1. Способ лечения болезни Альцгеймера у млекопитающих, включающий введение в спинномозговую жидкость (cerebrospinal fluid, CSF) млекопитающему частицы rAAV, содержащей капсидный белок rAAV и вектор, включающий нуклеиновую кислоту, кодирующую защитную изоформу белка АроЕ, вставленную между парой инвертированных концевых повторов AAV таким образом, который является эффективным для инфекции эпендимной клетки в млекопитающем,
