THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;DEPARTMENT OF VETERANS AFFAIRS;FABENE, PAOLO;CONSTANTIN, GABRIELA
发明人:
申请号：
EP07809438.0
公开号：
EP2029164B1
申请日:
2007.06.06
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy. The agent is a a selective antagonist, which binds to an adhesion molecule being a selectin or a ligand thereof, such as P-selectin glycoprotein ligand-1.
