YSEBAERT, NINA,伊斯伯特 妮娜,GOEYVAERTS, NELE ISA E.,高伊凡伯兹 尼尔,高伊凡伯茲 尼爾,ROYMANS, DIRK ANDRE EMMY,罗伊曼斯 德克,羅伊曼斯 德克,KOUL, ANIL,古勒 安尼尔,古勒 安尼爾
申请号：
TW107143199
公开号：
TW201936193A
申请日:
2018.12.03
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The present invention is directed to the combination of the RSV inhibiting Compound A, i.e. 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, and the RSV inhibiting Compound B, i.e. (1S,2S)-2-[4-[7-cyclopropyl-5-[(1R)-1-methyl-3,4-dihydro-1H-isoquinoline-2-carbonyl]pyrazolo[1,5-a]pyrimidin-2-yl]-3-fluoro-phenyl] cyclopropanecarboxylic acid for treating or ameliorating RSV infection. The invention further relates to the combination product of Compound A and Compound B, a pharmaceutical product comprising Compound A and Compound B, the use of the combination of Compound A and CompoundB-or the pharmaceutical product comprising Compound A and Compound B-for the treatment of RSV infection, and a method of treating or ameliorating RSV infection in a subject in need thereof comprising administering the combination of Compound A and Compound B in an effective amount to said subject.本發明涉及RSV抑制化合物A，即3-({5-氯-1-[3-(甲基磺醯基)丙基]-1H-吲哚-2-基}甲基)-1-(2,2,2-三氟乙基)-1,3-二氫-2H-咪唑并[4,5-c]吡啶-2-酮和RSV抑制化合物B，即(1S,2S)-2-[4-[7-環丙基-5-[(1R)-1-甲基-3,4-二氫-1H-異喹啉-2-羰基]吡唑并[1,5-a]嘧啶-2-基]-3-氟-苯基]環丙烷甲酸的組合用於治療或改善RSV感染。本發明進一步涉及化合物A和化合物B之組合產品、包含化合物A和化合物B之藥用產品、化合物A和化合物B的組合或包含化合物A和化合物B的藥用產品用於治療RSV感染之用途、以及治療或改善有需要的受試者的RSV感染之方法，該方法包括將化合物A和化合物B的組合以有效量給予所述受試者。
