CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.);UNIVERSIDAD AUTONOMA DE MADRID;CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
发明人:
REDONDO MOYA, JUAN MIGUEL,MENDEZ-BARBERO, NEREA,OLLER PEDROSA, JORGE,CAMPANERO GARCIA, MIGUEL RAMON
申请号：
CA3017042
公开号：
CA3017042A1
申请日:
2016.12.30
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention refers to an In vitro method for screening for subjects at risk of developing thoracic aortic aneurysm (TAA) or a disease causing TAA comprising: (a) measuring the expression pattern or level of at least A Disintegrin And Metalloproteinase with Thrombospondin Motifs 1 (ADAMTS1) obtained from an isolated biological sample of the subjects to be screened； and (b) comparing said expression pattern or level of at least ADAMTS1 of the subjects to be screened with an already established expression pattern or level, wherein reduced expression of at least ADAMTS1 is indicative of a thoracic aortic aneurysm (TAA).
