PROBLEM TO BE SOLVED: To provide a Jmjd3 gene-modified non-human mammal and a Jmjd3 gene-modified bone marrow chimera non-human mammal which are useful for screening of materials which control differentiation to a M2 macrophage, screening of therapeutic agents for M2 macrophage related diseases, such as parasitic infection response, wound healing, allergies, cancer, and arteriosclerosis, and the like, and a screening method for materials which control differentiation of a Jmjd3 gene-modified bone marrow cell derived from the mammals, a Jmjd3 gene-modified macrophage, and the M2 macrophage.SOLUTION: In the Jmjd3 gene-modified non-human mammal, a Jmjd3 gene in a genome is modified. The Jmjd3 gene-modified non-human mammal is a Jmjd3 gene homo-modified animal whose both alleles in a Jmjd3 gene are inactivated.COPYRIGHT: (C)2012,JPO&INPIT【課題】M2マクロファージへの分化を制御する物質のスクリーニング、寄生虫感染応答、創傷治癒、アレルギー、癌、動脈硬化等のM2マクロファージ関連疾患の治療薬のスクリーニング等に有用な、Jmjd3遺伝子改変非ヒト哺乳動物、Jmjd3遺伝子改変骨髄キメラ非ヒト哺乳動物、及びこれらの動物由来のJmjd3遺伝子改変骨髄細胞、Jmjd3遺伝子改変マクロファージ、並びにM2マクロファージの分化を制御する物質のスクリーニング方法を提供する。【解決手段】ゲノム中のJmjd3遺伝子が改変されているJmjd3遺伝子改変非ヒト哺乳動物。【選択図】なし
