RUE, SARAH,COHEN, STEVEN B.,LI, JUN,YOWE, DAVID LANGDON
申请号：
PE2012000801
公开号：
PE20121361A1
申请日:
2010.12.10
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
An antibody associated with Pro protein convertasa subtilisina / quexina 9 (PCSK9) includes: (a) a heavy chain variable region, including a heavy chain part-v, a heavy chain decisive complementary region (CDR3), a heavy chain structural region 4 (FR4), and (b) a heavy chain structural region The variable region of light chain consists of human light chain segment VA decisive complementary region 3 (CDR3) in the light chain and a structural region 4 (FR4) in the light chain, among which (I) the report of the Third United Nations Conference on the exploration and peaceful uses of outer space (UNISPACE III) of the Third United Nations Conference on the exploration and peaceful uses of outer space (UNISPACE III) (A / F / S / V / y) (SEQ ID No.14) and (II) of the Third United Nations Conference on the exploration and peaceful uses of outer space (UNISPACE III) in the heavy chainThe light chain is composed of lqwssdppt (SEQ ID No: 26) amino acid sequence. These antibodies do not impede the link between PCSK9 and LDLR, nor the degradation of LDLR facilitated by PCSK9.REFERIDA A UN ANTICUERPO QUE SE ENLAZA A LA PRO-PROTEINA CONVERTASA-SUBTILISINA/QUEXINA TIPO 9 (PCSK9) QUE COMPRENDE: a) UNA REGION VARIABLE DE CADENA PESADA QUE COMPRENDE UN SEGMENTO-V DE CADENA PESADA HUMANO, UNA REGION DETERMINANTE DE COMPLEMENTARIEDAD 3 (CDR3) DE LA CADENA PESADA Y UNA REGION DE ESTRUCTURA 4 (FR4) DE LA CADENA PESADA Y b) UNA REGION VARIABLE DE CADENA LIGERA QUE COMPRENDE UN SEGMENTO-V DE CADENA LIGERA HUMANO, UNA REGION DETERMINANTE DE COMPLEMENTARIEDAD 3 (CDR3) DE LA CADENA LIGERA Y UNA REGION DE ESTRUCTURA 4 (FR4) DE LA CADENA LIGERA DONDE i) LA CDR3 DE LA CADENA PESADA COMPRENDE LA SECUENCIA DE AMINOACIODS SYYYY (A/N)MD(A/F/S/V/Y) (SEQ ID NO:14) Y ii) LA REGION VARIABLE DE LA CDR3 DE LA CADENA LIGERA COMPRENDE LA SECUENCIA DE AMINOACIDOS LQWSSDPPT (SEQ ID NO:26). DICHOS ANTICUERPOS NO BLOQUEAN EL ENLACE DE PCSK9 AL RECEPTOR DE LIPOPROTEINA DE BAJA DENSIDAD (LDLR) E INHIBEN LA DEGRADACI
