A rodent cage for housing a rodent comprises a cage body having an open bottom end and an open top end defined by integral sidewalls. An interior surface of each sidewall is adapted to carry a channel. The top end of at least one sidewall terminates below the channel to slidably accept a top panel within the channel. The top panel has at least one opening therein for passage of laboratory equipment. A tray having a bottom and upwardly extending integral tray sidewalls is proportioned so that the cage body rests within the tray during use. The cage body further includes a floor of parallel spaced rods such that bedding housed within the cage body passes through the spaces between the rods while the rodent remains within the cage body when the cage body is removed from the tray. The rodent cage is constructed of a non-permeable clear acrylic plastic.