A vial access device, comprising a body (1) having a projecting annular skirt (21) that is elastically deformable, for engaging the complementary shaped neck of a vial, a tubular spike (15) extending coaxially within said annular skirt (21) for introducing into the vial, and a tubular connector (3) protruding from the body (1) on the side opposite to the annular skirt (21) and in fluid communication with the tubular spike (15). The tubular spike (15) and the annular skirt (21) are arranged, respectively, within a first and a second part (13, 14), distinct from each other, and of which the first part (13) is permanently joined to the body (1) and the second part (14) is connectable to the first part (13) through an irreversible coupling (26, 27).
