Described are mitochondria-targeted anti-tumor agents, and methods of makingand using the same for the treatmentof disorders associated with unwanted cell proliferation. In one aspect, theinvention provides compositions having theformula: A-B, wherein A is a molecular chaperone inhibitor and B is amitochondria-penetrating moiety and A and B are linked,optionally by a linking moiety and pharmaceutically acceptable salts.
