BEIJING INSTITUTE OF GENOMICS, CHINESE ACADEMY OF SCIENCES;Linzhao Cheng
发明人:
Linzhao Cheng,Qianfei Wang,Yueying Li
申请号：
US16345600
公开号：
US20200022998A1
申请日:
2017.10.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention belongs to the fields of cell biology and medicine, and relates to the medical use of NOTCH4 or the medical use of NOTCH4 inhibitors. In particular, the invention relates to use of NOTCH4 protein or NOTCH4 gene for manufacture of a medicament for promoting hematopoietic stem/progenitor cell differentiation and megakaryocyte differentiation in a mammal, a medicament for treating megakaryocyte dysplasia, or a medicament for promoting platelet production. The invention can effectively promote the production of hematopoietic stem/progenitor cells and megakaryocytes in vitro, thereby significantly improving the efficiency of platelet production in vitro, and having a good application prospect.
