CHUGAI SEIYAKU KABUSHIKI KAISHA;THE UNIVERSITY OF TOKYO;FORERUNNER PHARMA RESEARCH CO LTD.
发明人:
申请号：
IL19791409
公开号：
IL197914A
申请日:
2009.04.05
申请国别(地区):
IL
年份:
2014
代理人:
摘要：
Methods that entail detection of an epiregulin (EREG) protein for cancer diagnosis are disclosed. In colon cancer, lung adenocarcinoma, pancreatic cancer, stomach cancer, and kidney cancer, the gene and protein expressions of EREG were frequently found to be elevated. Antibodies that recognize an EREG protein are used for diagnosing or treating cancer in the present invention. Pharmaceutical compositions, cell proliferation inhibitors, and anticancer agents containing an EREG-binding antibody as an active ingredient are also disclosed. Methods of inducing cell damage in EREG-expressing cells and methods of suppressing the proliferation of EREG-expressing cells by contacting the EREG-expressing cells with EREG-binding antibodies are also disclosed.
