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СВЯЗЫВАЮЩИЕСЯ С SDF-1 НУКЛЕИНОВЫЕ КИСЛОТЫ И ИХ ПРИМЕНЕНИЕ ПРИ ЛЕЧЕНИИ РАКА
专利权人:
НОКСОН ФАРМА АГ (DE)
发明人:
ПУРШКЕ Вернер (DE),ЯРОШ Флориан (DE),ОЙЛБЕРГ Дирк (DE),КЛУССМАНН Свен (DE),БУХНЕР Клаус (DE),МААШ Кристиан (DE),ДИНЗЕ Николь (DE),ЦБОРАЛЬСКИ Дирк (DE)
申请号:
RU2013115739/10
公开号:
RU2013115739A
申请日:
2011.09.09
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A nucleic acid molecule capable of binding to SDF-1, preferably capable of inhibiting SDF-1, whereby the nucleic acid molecule is for use in a method of treatment and / or prevention of a disease or disorder for use in a method of treating a subject, suffering from a disease or disorder or at risk of developing the disease or disorder, as adjuvant therapy or for use as a medicament for the treatment and / or prevention of diseases or n arusheniya, whereby the disease or disorder is rak.2. A nucleic acid molecule according to Claim. 1, whereby the cancer is a cancer selected from the group of malignant tumors of the hematopoietic system and solid tumors, in accordance with what is preferably a cancer of the hematopoietic system selected from the group consisting of leukemia and myeloma, and solid tumors selected from the group consisting of glioblastoma, colorectal cancer, breast cancer, lymphoma, prostate cancer, pancreatic cancer, renal cancer, ovarian cancer and cancer legkogo.3. The nucleic acid molecule according to Claim. 1, whereby the adjunct therapy sensitizes the subject, wherein the subject is sensitized more able to respond to a therapy for treating and / or preventing a disease or narusheniya.4. A nucleic acid molecule according to claim. 3, whereby the treatment for the treatment and / or prevention of a disease or disorder comprising administering an additional pharmaceutically active agent, and / or exposure of the subject and / or surgical
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