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Methods and compositions for vaccinating a subject for a sexually transmitted pathogen
专利权人:
发明人:
Paola Massari,Guillermo Madico,Luis de la Maza
申请号:
US15448767
公开号:
US20170252424A1
申请日:
2017.03.03
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly immunogenic and elicit cross-serovar neutralizing monoclonal and polyclonal antibodies and T cell responses in animal and human models. Examples herein provide a method for vaccinating a subject against Chlamydia using a composition that is a recombinant Neisseria porin that contains at least one antigenic variable domain of Chlamydia. The variable domains are inserted into the amino acid sequence of the Neisseria porin at a position encoding a surface-exposed loop of the Neisseria porin. The vaccine further contains an adjuvant that induces a Th1 response greater than a Th2 response.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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