ANAGNOSTIS- IOANNIS TSOUKALAS,ANNA PATERA,KONSTANTINOS GARDIKIS,NIKOLAOS KOUTSIANAS,PANAGIOTA DRAGANI,SOFIA LETSIOU
申请号：
BR112018010432
公开号：
BR112018010432A2
申请日:
2015.11.23
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
A method for preparing a stable controlled release propolis colloidal dispersion system, wherein the propolis - after frozen for 24 hours - is micronized and then dispersed in the stirred solvent system consisting of deionized water at 25 ° C or in 1,3-propanediol or natural glycerol in a 1,3-propanediol (or glycerol) / water mixture ratio of 15% / 85% to 80% / 20%, wherein hydroxypropyl-ß-cyclodextrin deionized water or ß-cyclodextrin has been pre-dissolved to 2-10% w / w, and as the propolis / cyclodextrin / solvents system is under intense agitation for 30-45 min at a temperature of 20 ° to 38 ° c, a liposomal suspension 0.3 to 3.5% w / w is added thereto, and stirring is performed for 1 to 4 hours under continuous measurement of the total polyphenol content and the encapsulation efficiency percentage until the specific parameters reach the desired values for the agitation process to be completed and the system to The colloidal membrane is filtered through suitable filters, its pH is adjusted and the size of the dispersed particles, as well as the release rate of the propolis polyphenols in a buffer solution at pH 7.2 and 37 ° C are measured and the colloidal system is measured. It is stored in a dark colored container at a temperature of 5-7 ° C. The colloidal system is suitable for use as a cosmetic ingredient, food supplement, nutraceutical and as a component in functional foods. It is considered effective for antioxidant, angiogenic, photoprotective, antimicrobial and immunostimulant use.método para preparar um sistema de dispersão coloidal de própolis de liberação controlada estável, em que o própolis - depois de congelado por 24 horas - é micronizado e então disperso no sistema solvente, que está sob agitação e consiste em água deionizada a 25°c e ou em 1,3-propanodiol ou glicerol natural em uma razão de mistura de 1,3-propanodiol (ou glicerol)/água de 15%/85% a 80%/20%, em que a água deionizada hidroxipropil-ß-ciclodextrina ou ß-ciclodextrina já foi pré-di
