Centers for Disease Control and Prevention;The Government of the United States of America as represented by The Secretary; Department of Health and Human Services
发明人:
Chang, Gwong-Jen J.
申请号：
AU2010202127
公开号：
AU2010202127B2
申请日:
2010.05.26
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010202127B220120405.pdf#####ABSTRACT The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a 5 second flavivirus or of a chimeric immunogenic flavivirus antigen comprising sequence from more than one flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or 10 diagnosing flavivirus infection.
