A preparation method of medical-grade hydrophilic implant is disclosed.The preparation method comprises the following steps of: providing an implant, performing a sandblasting and acid etching process to roughen the implant with a surface roughness, performing an oxygen plasma surface modification process to activate the surface of the implant and performing a hydroxylation process to form the peroxide group or the hydroxide group on the surface of the implant to raise the surface hydrophility of the implant.本發明係揭露一種醫療級親水性植體之製作方法,其至少包含下列步驟:提供一植體;對植體進行噴砂酸蝕處理,用以粗糙化植體而使植體具有一表面粗糙度;對植體進行氧氣電漿表面改質步驟,用以活化植體之表面;以及對植體進行羥基化反應步驟,用以於植體之表面形成過氧化基或氫氧基,以提高植體之表面親水性。S10...提供植體S20...噴砂酸蝕處理S30...氧氣電漿表面改質步驟S40...羥基化反應步驟