Jay Copeland Strum,John Emerson Bisi,Patrick Joseph Roberts,Ricky D. Gaston,Robert C. Gadwood
申请号：
US14690219
公开号：
US20150297607A1
申请日:
2015.04.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention is in the area of tricyclic lactam compounds, compositions and methods of protecting healthy cells, and in particular hematopoietic stem and progenitor cells (HSPC) as well as renal cells, from damage associated with DNA damaging chemotherapeutic agents. In one aspect, protection of healthy cells is disclosed using compounds that act as cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors when administered to subjects undergoing DNA damaging chemotherapeutic regimens for the treatment of proliferative disorders.
