This invention relates to a device for preventing drooling of saliva and in particular, this invention relates to a device for preventing drooling of saliva which is made with Poly-methyl methacrylate or with medical-grade plastic. More particularly, this present invention relates to the device for preventing drooling of saliva having a head-strap and chin guard to prevent drooling caused post- surgically. Furthermore, this invention also relates to the device for preventing drooling of saliva which has the advantages of reasonable structure, protecting effect is good, and the mounting process is simple and direct, safe and reliable and environment friendly and simple to use.