SAYRE, Richard,VINOGRADOVA-SHAH, Tatiana,SINEVA, Elena,COSTA-NUNES, Pedro
申请号：
WO2018US33976
公开号：
WO2018217819(A1)
申请日:
2018.05.22
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
The inventive technology may include novel systems for regulation of the expression of bacterial genes through the introduction of antisense RNA (asRNA) that may disrupt expression of targeted pathogenic genes and/or their products (mRNA, proteins). In some embodiments, the inventive technology may include novel genetically engineered donor bacterial strains that are configured to efficiently and continuously deliver asRNA polynucleotides to a recipient pathogen and downregulate expression or one or more essential genes.
