The present invention relates generally to methods of treating fibrotic disease and more specifically to an inhibitor of CSF1-R activity for the treatment and/or prophylaxis of fibrotic disease, wherein the inhibitor comprises a small chemical entity (NCE), a nucleic acid or an antibody or functionally active fragment or derivative thereof. The present invention further pertain the use of an inhibitor of CSF-1R activity, for the manufacture of a medicament for the treatment and or prophylaxis of fibrotic disease.
