Novel heterocyclic derivatives and their uses

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专利权人:

주식회사 씨앤드씨신약연구소

发明人:

호필수,윤동오,한선영,이원일,김정숙,박월성,안성오,김혜정

申请号：

KR1020147010409

公开号：

KR1018007490000B1

申请日:

2012.09.28

申请国别(地区):

KR

年份:

2017

代理人:

摘要：

The present invention relates to novel heterocycle compounds useful in the manufacture of medicaments for the treatment of diseases associated with various functions of the histamine 4 receptor, said medicament being particularly useful for the treatment of inflammatory disorders, allergy, pain, nasal polyposis nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, prurtis, itch skin, urticaria, idiopathic chronic urticaria, scleroderma atherosclerosis, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, atherosclerosis, inflammatory pain, neuropathic pain, inflammatory bowel disease, inflammatory bowel disease (including Crohn's disease, ulcerative colitis), multiple sclerosis, multiple sclerosis, multiple sclerosis, Osteoarthritic pain, autoimmune thyroid disease, immune mediated (also known as type 1) diabetes, lupus, post-operative adhesions, vestibular disorder, And is useful for the treatment of cancer and the like.본 발명은 히스타민 4 수용체의 다양한 기능과 연관된 질병을 치료하는 의약의 제조에 유용한 신규한 헤테로사이클 화합물에 관한 것으로서, 상기 의약은 특히, 염증 장애, 알러지(allergy), 통증(pain), 비강 용종(nasal polyps), 비염(rhinitis), 만성 부비동염(chronic sinusitis), 비충혈(nasal congestion), 코 가려움증(nasal itch), 천식(asthma), 만성 폐색성 폐질환(chronic obstructive pulmonary disease), 류마티스 관절염(rheumatoid arthritis), 아토피성 피부염(atopic dermatitis), 건선(psoriasis), 습진(eczema), 소양증(prurtis), 피부 가려움증(itch skin), 두드러기(urticaria), 특발성 만성 두드러기(idiopathic chronic urticaria), 경피증(scleroderma), 결막염(conjunctivitis), 각결막염(keratoconjunctivitis), 안염(ocular inflammation), 안구 건조증(dry eye), 심장 기능장애(cardiac dysfunction), 부정맥(arrhythmia), 아테롬성 동맥 경화증(atherosclerosis), 다발성 경화증(multiple sclerosis), 염증성 장 질환(대장염(colitis), 크론병(Crohn's disease), 궤양성 대장염(ulcerative colitis) 포함), 염증성 통증(inflammatory pain), 신경성 동통(neuropathic pain), 골관절염 통증(osteoarthritic pa

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