KHADD Majkl Dzh. (US),ХАДД Майкл Дж. (US),KHOKER Majkl D. (US),ХОКЕР Майкл Д. (US),KHOLLADEJ Mark U. (US),ХОЛЛАДЭЙ Марк У. (US),LYU Gan (US),ЛЮ Ган (US),ROUBOTTOM Martin U. (US),РОУБОТТОМ Мартин У. (U,KHADD Majkl Dzh.,ХАДД Майкл Дж.,KHOKER Majkl D.,ХОКЕР Майкл Д.,KHOLLADEJ Mark U.,ХОЛЛАДЭЙ Марк У.,LYU Gan,ЛЮ Ган,ROUBOTTOM Martin U.,РОУБОТТОМ Мартин У.,SYUJ Shimin,СЮЙ Шиминь
申请号：
RU2014119244
公开号：
RU0002648997C2
申请日:
2012.10.12
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound having the formula VIIb:VIIb,wherein each of R1 and R2 is hydrogen； R3 is hydrogen or C1-6alkyl； each Q1 independently is halogen, oxo, C1-6alkyl, -RuORx, -RuSRx, =NORd, where alkyl groups are optionally substituted with one hydroxyl； Y is -(CR5R6)q-； Z is O or S； each W is independently CR8 or N； W1 is N or C； W2 is N or C； W4 is N； W5 is N or CR13； R13 is hydrogen or Q2； each of Q5 and Q6 independently represents hydrogen, halogen, cyano, C1-6alkyl, halogen C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C3-7cycloalkenyl, 5-6 membered heteroaryl with one to four nitrogen atoms, 6-membered heterocyclyl with one to two heteroatoms independently selected from a nitrogen atom and oxygen, 6-membered partially unsaturated heterocyclyl with one heteroatom selected from a nitrogen atom and oxygen, (6-membered heterocyclyl with two heteroatoms independently selected from nitrogen atom and oxygen)-C1-6alkyl, -RuORx, -RuN(Ry)(Rz), -RuSRx, -RuC(J)Rx, -RuC(J)ORx, -RuC(J)N(Ry)(Rz), -RuC(J)C1-6alkyl-N(Ry)(Rz), -RuC(J)N(Ry)ORx, -RuS(O)tRw, -RuN(Rx)C(J)Rx or -C(=NORx)Rx, where the alkyl, alkenyl, alkynyl, heteroaryl and heterocyclyl groups are optionally substituted with one to three Q groups8； J is O or NRx； each t is 2； and q is 0 or 1； values of other radicals are given in the patent claim. Invention also relates to pharmaceutical composition, to method for treating a disease and to a method for modulating a kinase CSF1R, FLT3, KIT and/or PDGFRβ.EFFECT: technical result: new compounds of formula VIIb, which are kinase modulators CSF1R, FLT3, KIT and/or PDGFRβ.20 cl, 6 dwg, 4 tbl, 242 exИзобретение относится к соединению, характеризующемуся формулой VIIb:VIIb,в которой каждый из R1 и R2 представляет собой водород； R3 представляет собой водород или С1-6алкил； каждая Q1 независимо представляет собой галоген, оксо, С1-6алкил, -RuORx, -RuSRx, =NORd, где алкильные группы необязательно замещены одним гидроксилом； Y пред
