LANTHIER CHRISTOPHER M.,GORIN BORIS,OUDENES JAN,DIXON CRAIG EDWARD,LU ALAN QUIGBO,COPP JAMES DENSMORE,JANUSZ JOHN MICHAEL
申请号：
NZ61857012
公开号：
NZ618570A
申请日:
2012.06.05
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino} acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino} acetic acid esters and { [3-hydroxypyridine-2-carbonyl]amino} acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.
