The nonsteroidal SGRM may be a nonsteroidal compound comprising: a fused azadecalin structure； a heteroaryl ketone fused azadecalin structure； or an octahydro fused azadecalin structure. Pharmaceutical compositions comprising a chemotherapeutic agent and a GRM are disclosed. The GRM in such pharmaceutical compositions may be a nonsteroidal GRM, and may be a SGRM, such as a nonsteroidal SGRM. The nonsteroidal SGRM may comprise: a fused azadecalin structure； a heteroaryl ketone fused azadecalin structure； or an octahydro fused azadecalin structure.
