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ЦИКЛИЧЕСКИЕ АЗАИНДОЛ-3-КАРБОКСАМИДЫ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ
专利权人:
发明人:
ШТАЙНХАГЕН Хеннинг (DE),ShTAJNKhAGEN Khenning (DE),ШАЙПЕР Бодо (DE),ShAJPER Bodo (DE),МАТТЕР Ханс (DE),MATTER Khans (DE),МАККОРТ Гари (FR),MAKKORT Gari (FR)
申请号:
RU2010136323/04
公开号:
RU0002487874C2
申请日:
2009.01.17
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to cyclic azaindole-3-carboxamides of formula (I) in any of its stereoisomeric forms or in the form of a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof or a physiologically acceptable solvate of any of them: wherein A is specified in O, S and C(Ra)2 Ra is specified in hydrogen and (C1-C4)-alkyl wherein the two groups Ra are independent from each other and may be identical or different R is specified from hydrogen, (C1-C4)-alkyl, hydroxy-(C1-C4)-alkyl-, (C1-C4)-alkyl-O-(C1-C4)-alkyl-, phenyl-(C1-C4)-alkyl-, (C1-C4)-alkyl-O-CO-CuH2u- and R1-NH-CO-CuH2u-, wherein all the groups R are independent from each other and may be identical or different R1 is specified from hydrogen, (C1-C4)-alkyl and H2N-CO-(C1-C4)-alkyl- R10 is specified from hydrogen, (C1-C6)-alkyl-O-CO- R20 is specified from phenyl which is optionally substituted by one or more identical or different substitutes specified in halogen, (C1-C4)-alkyl and (C1-C4)-alkyl-O- R30 is specified from (C3-C7)-cycloalkyl and phenyl, wherein phenyl is optionaly substituted by one or more identical or different substitutes specified in halogen and (C1-C6)-alkyl R40 is specified in halogen, (C1-C4)-alkyl, phenyl-(C1-C4)-alkyl-, hydroxy, (C1-C4)-alkyl-O-, HO-CO-(C1-C4)-alkyl-O- and (C1-C4)-alkyl-O-CO-(C1-C4)-alkyl-O-, wherein all the substitutes R40 are independent from each other and may be identical or different one of the groups Y1, Y2, Y3 and Y4 represents N, while the others are identical or different groups CH or CR40 n is specified in 0, 1, 2 and 3 p and q which are independent from each other and may be identical or different being specified in 2 and 3 n is specified in 0, 1 and 2, wherein all the values are independent from each other and may be identical or different wherein all the alkyl groups are independently from each other optionally substituted by one or more fluorine atoms wherein all the phenyl g
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