C. R. King,Micheal J. Caulfield,Ivo C. Lorenz,Christopher L. Parks
申请号：
US13661737
公开号：
US20130129778A1
申请日:
2012.10.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to generating a vaccine based on immunogens from viral particles that initially have replication competency but are then inactivated by chemical, biophysical or other methods. The components of this vaccine may be a non-HIV enveloped virus that contains and expresses a gene related to the HIV Envelope gene such that the Envelope protein is expressed on the surface of viral particles. These viral particles may be further treated to reduce their replication competency. The vaccine further may contain components to improve its immunogenicity, tolerability, stability and ease of manufacture.
