Christoph SCHMITZ,Mohammad SAMETI,Andreas KOCH,Michael HORSTMANN
申请号：
US16715972
公开号：
US20200113819A1
申请日:
2019.12.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention relates to a composition for transdermal delivery, particularly iontophoretic transdermal delivery, of at least one cationic active agent or a salt thereof. The composition includes at least one cationic active agent or a salt thereof, at least one polyamine or/and polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. The invention further relates to the use of such composition as a component of a transdermal patch or of an iontophoretic transdermal patch, as well as to the use of such composition in a method for transdermally and/or iontophoretically administering cationic active agents. The invention further includes methods for determining the in vitro skin permeation properties of an active-agent-containing iontophoretic composition.
